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Retained consciousness Sudden loss of muscle tone with sudden return of muscle tone after the episode Loss of muscle tone is bilaterally symmetrical Reversible loss of deep tendon reflexes in involved limbs during episodes Respiratory muscles arent involved, but people sometimes have shortness of breath Triggered by strong emotions, usually positive, such as the emotions associated with laughter Brief lasts less than 2 minutes (usually less than 30 seconds) Variable frequency at least 3 lifetime episodes ranging from once every few months to more than 20 per day (usually at least 1 episode a month if untreated) Improvement with medicines that treat cataplexy Can be partial or complete cataplexy, but usually partial Whats the difference between partial and complete cataplexy

Differential association of receptor-Gbetagamma complexes with beta-arrestin2 determines recycling bias and potential for tolerance of delta opioid receptor agonists

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It signals fibroblasts to build collagen and elastin, activates angiogenesis (new capillary growth), reduces inflammatory cytokines like TNF-alpha, and helps stem cells migrate to repair sites